I'd like to highly recommend Akal Anaimal Hospital on Berryessa Rd in San Jose. I have a big loveable English Mastiff named Babe; but she can get a little bit nasty when the veterinarians touch her. But the doctors and staff at Akal were very patient with her and very gently tranquilized her and carefully watched over her while they examined her and woke her back up. It's tough to find an animal hospital that can work with big dogs like my 160 pound baby, but the doctors and staff at Akal Animal Hospital did a wonderful job.
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