The San Diego Holiday Inn Express Hotel in Otay Mesa welcomes you! This choice San Diego hotel is nestled in the heart of the Otay Mesa Industrial Business Park, a short drive from downtown San Diego and less than a mile from beautiful Tijuana, Mexico. Our new hotel in San Diego offers a convenient suburban location near the Cricket Wireless Amphitheatre, Knott's Soak City Water Park, Sea World, the Chula Vista Olympic Training Park and the famous San Diego Zoo. Your family can learn about local history at the Cabrillo National Monument, the Air and Space Museum and the Maritime Museum. For some great bargains, check out Las Americas Premium Outlets with 125 outlet stores and 13 restaurants in a lovely outdoor setting, or try the Otay Town Center Mall, just four miles from our San Diego hotel. Business travelers will enjoy a stay at our San Diego hotel because of its convenient location near companies such as Toyota, Bose, Panasonic, Maxwell, Tyco, JVC, Siemens Medical and Samsung, each within six miles of our San Diego hotel in the Mesa Otay Industrial Park. The International Commercial Border Crossing is .25 miles away. The Brown Field Municipal Airport is three miles away. During your stay, enjoy a free hot breakfast, Fitness Center and outdoor pool with Jacuzzi. Check out our San Diego hotel room deals to start planning your trip today.