Welcome to the Holiday Inn Express Florence Hotel This premiere Holiday Inn Express hotel is conveniently situated on Hwy 327 and I-95 in Florence, SC. Our hotel's location in the suburbs takes you away from the city's hustle and bustle while keeping you close to important sites like Florence Regional Airport. When you're looking for convenient business hotels in Florence, the Holiday Inn Express hotel is a perfect choice. We're surrounded by companies, including Angus-Palm, Beneteau, Blanchard Machinery, DuPont, FedEx, HJ Heinz, Honda, IFH, Johnson Controls, Monster, NuCor Steel, Pepsi, Roche Carolina, Smurfit-Stone and QVC. We're also just minutes from Francis Marion University. Professional guests can host events in our 60-person meeting room or utilize the services in our 24-hour business center. Leisure guests love the convenience of our hotel's Florence locale.