Alton Hotel's Inviting Atrium Atmosphere Impresses With a convenient and practical location near the confluence of the Mississippi and Missouri Rivers, the Holiday Inn Alton hotel offers a genuine value to travelers. Located at the intersection of Route 140 and Route 3, and within minutes of I-255, I-270, and the Amtrak Station, this hotel boasts unparalleled amenities and the friendliest staff, as well as ideal proximity to downtown Alton. The hotel's business guests in Alton, IL find themselves well-situated to reach the city's major area corporations, colleges and the wide array of small businesses. ConocoPhillips, Global Brass and Copper, Inc and American Water are all just a stone's throw away. Take advantage of the free shuttle to and from Amtrak, local businesses, SIU Dental School and Lewis and Clark Community College.