Located down by the World Trade Center, the Harpoon brewery isn't near very much. Aside from taking the new silver line into the area, you probably have to drive. The Brewery has a few big festivals every year, the highlight probably being the Oktoberfest. It is $12 to get in and then you still have to pay for food and beer, but the beer is fresh and there are traditional German OOM PA PA (sp?) bands rocking out. It's a great time. Otherwise, just pop in and take a tour, or better yet, go straight to the gift shop and fill up a huge Growler bottle with your favorite beer to take home for only $5. It doesn't get much better than that.
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