Choose the Holiday Inn Express Sanford / Lake Mary Conveniently located off Interstate 4, approximately 20 miles from Orlando, you'll find our contemporary Holiday Inn Express hotel. Near the Sanford, Florida airport and just three miles from Amtrak station, our convenient location makes travel easy for business and leisure guests alike. Business guests can have a successful stay at the Holiday Inn Express hotel in Sanford by using the free wireless Internet access and the 24-hour business center. We are conveniently located near Lake Mary and Heathrow. You can even meet with clients in our 600-sq ft space, suitable for up to 50 people. Whether you feel like touring attractions like the Central Florida Zoo, taking an easy drive to Disney and Orlando's Universal Studios or relaxing outside on our stone terrace with a charcoal grill, there are plenty of fun, exciting activities to do in and near our Lake Mary area hotel. Other nearby family-fun attractions include the Sanford Marina and Daytona Speedway. Guests who Stay Smart at our hotel near the Sanford, Florida airport enjoy free perks like an airport shuttle (shuttle hours 530a - 930p), Internet access and a delicious, hot breakfast every morning. So, retreat to the Sunshine State and experience the best of central Florida with a name you can trust and at a price you can afford. Now Accepting Corporate Lodging